pentobarbital will reduce the extent or impact of fludrocortisone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.pentobarbital decreases outcomes of sufentanil SL by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration of CYP3A4 inducers may decrease sufentanil range